Bacteria Source: www.commons.wikimedia.org |
Today’s world population is infected
with the increased amount of bacterial infections as compared to those who
lived 10 years before and during that time bacteria have learned to survive. Even
they escape the same antibiotics from which they would usually die. In other
words, now bacteria are not coming in handy anymore with many types of
antibiotics.
Many bacterial infections such as
tuberculosis, gonorrhea, and staphylococcus aureus infections have shown to
become nearly impossible to treat when they are caused by multi-drug-resistant
bacteria.
Antibiotics function is to
destroy or inhibit a specific part of the bacterium such as its growth, DNA
formation and cell wall synthesis. Additionally, there are many other ways
antibiotics are utilized to kill bacteria.
In order to combat
multi-drug-resistant bacteria, researchers are finding ways to replace the old list
of antibiotics with new one that will work in a different way.
The team of doctors under the
patronage of Joseph Pogliano and Kit Pogliano from the University of California
has tested if it was possible to quickly identify the bacteria by observing their
shape, appearance and whether it was possible to identify which antibiotics
class would be possible to target their structure. It was concluded that knowing
the features of culprit bacteria can provide some clue on what type of
antibiotics can be used to kill the bacteria.
Various measurements like size, shape and everything were thoroughly observed. The findings were that the antibiotic list of the same class can be grouped together by a method called bacterial cytological profiling (BCP).
Bacterial cytological profiling
A research was carried out in which Escherichia Coli (E. Coli) was used to study further the mechanism of already known antibiotics.Various measurements like size, shape and everything were thoroughly observed. The findings were that the antibiotic list of the same class can be grouped together by a method called bacterial cytological profiling (BCP).
To test whether BCP can help
differentiating the pathways or not, it was targeted by different antibiotics. The
scientists put 18 known compounds to test the affectivity of BCP. They placed
it into 3 separate groups of 10 and blindly exposed E. coli cells to each of
them. BCP seemed able to assign correctly all 30 compounds to their exact
cellular targets.
BCP is rendered as a single-step
method to determine the cellular targets of various compounds or drugs. Thus BCP
can help the scientist to distinguish between many bacteria and finding the
exact antibiotic.
Medicine holds a lot of promises
for progress in the future and it will shine further if proper resources and valuable
time is sacrificed which can result in greater discoveries.
Reference
Nonijuie P, Burkart M, Pogliano K,
Prgliano J. Bacterial cytological profiling rapidly identifies the cellular
pathways targeted by antibacterial molecules. Proc Natl Acad Sci 2013;110(40):16169-74.
Wendelsdorf K. Method quickly assesses
antibiotics [Internet]. 2013 Sep 30 [Cited
2013 Oct 5]. Available from: http://www.nih.gov/researchmatters/september2013/09302013antibiotics.htm.
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