Saturday, March 12, 2016

Steroid Doses in Different Conditions

Dose of steroids is different in different medical conditions. Below are some mentioned doses of steroids: 

Dose of steroids in the patients with space occupying lesion (SOL):

Dexamethasone 0.4–1.5 mg/kg/day, 6 hourly is given as it reduces vasogenic cerebral edema due to tumors, inflammation or infection, and has minimal mineralocorticoid activity. Steroids may be harmful in traumatic brain injury, ischemic lesions, subarachnoid hemorrhage (SAH) and cerebral malaria.

Dose of steroids in the patients with bacterial meningitis:

Dexamethasone 0.4 or 0.6 mg/kg per day in 4 divided doses for 4 days.

Steroid Dose in the patients with tuberculous meningitis

IV Dexamethasone is given for 4 weeks followed by a tapered dose of oral dexamethasone for next 4 weeks.
  • First week: 0.4 mg/kg per day
  • Second week: 0.3 mg/kg per day
  • Third week: 0.2 mg/kg per day
  • Fourth week: 0.1 mg/kg per day
  • Fifth week: 4 mg/day
  • Sixth week: 3 mg/day
  • Seventh week: 2 mg/day
  • Eigth week: 1 mg/day

Keywords: Steroids, Doses, Space occupying lesion, SOL, Bacterial meningitis, Tuberculous meningitis, TBM, Infections

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